Central sensitisation is more common than you may think

Clifford Woolf recently said this about central sensitisation: Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, aftersensations, and enhanced temporal summation. It […]

Pain Neuromatrix

The pain neuromatrix was a concept that came from Ron Melzack who partnered Pat Wall in developing our understanding of pain in a modern sense. Moving on from the Pain Gate Theory, Melzack described a widespread distribution of neurons (brain cells) that imprint a ‘neurosignature’ upon nerve impulse patterns that pass through the matrix. The […]